NOTE: Products used in these studies were named Prolact+ H2MF® and Prolact CR®. The formulation of Prolact+ H2MF® and HumavantTM HMF is the same. The formulation of Prolact CR® and HumavantTM CR is the same. Prolact+ H2MF® and Prolact CR ® are the trade names in North America, and HumavantTM HMF and HumavantTM CR are the trade names outside North America.



Reduction in Cost of Care

Huston RK, et al. "Decreasing Necrotizing Enterocolitis and Gastrointestinal Bleeding in the Neonatal Intensive Care Unit: The Role of Donor Human Milk and Exclusive Human Milk Diet in Infants Less 1500 g birth weight.ICAN: Adult Child and Adolescent Nutrition. 20 August 2013. 13:127. doi: 10.1186/1471-2431-13-127

 

Ganapathy V, et al. “Costs of Necrotizing Enterocolitis and Cost-Effectiveness of Exclusively Human Milk-Based Products in Feeding Extremely Premature Infants.” Breastfeeding Medicine. February 2012. 7(1):29-37. doi: 10.1089/bfm.2011.0002.

 

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

 

Reduction of NEC (Necrotizing Enterocolitis)

 

Huston RK, et al. "Improving Growth for Infants ≤1250 Grams Receiving an Exclusive Human Milk Diet." Nutrients. February 2018.  doi: 10.1002/ncp.10054.

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

Hermann K, et al. “An Exclusively Human Milk Diet Reduces Necrotizing Enterocolitis.” Breastfeeding Medicine. May 2014.  9(4): 184–190. doi: 10.1089/bfm.2013.0121

Cristofalo EA, et al. “Randomized Trial of Exclusive Human Milk versus Preterm Formula Diets in Extremely Premature Infants.” The Journal of Pediatrics. December 2013. 163 (6):1592-1595. doi: 10.1016/j.jpeds.2013.07.011

Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459

Huston RK, et al. "Decreasing Necrotizing Enterocolitis and Gastrointestinal Bleeding in the Neonatal Intensive Care Unit: The Role of Donor Human Milk and Exclusive Human Milk Diet in Infants Less <= to 1500 g birth weight.ICAN: Adult Child and Adolescent Nutrition. 20 August 2013. 13:127. doi: 10.1186/1471-2431-13-127

 

Sullivan S, et al. “An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products.” The Journal of Pediatrics 2010. doi: 10.1016/j.jpeds.2009.10.040.
 

Growth


Visuthranukul C, Abrams SA, Hawthorne KM, et al. Premature small for gestational age infants fed an exclusive human milk-based diet achieve catch-up growth without metabolic consequences at 2 years of age." Archives of Disease in Childhood - Fetal and Neonatal Edition Published Online First: 13 November 2018. doi: 10.1136/archdischild-2017-314547

Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. 
Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk FortifierBreastfeed Med. 2017;12(9):570–573. doi:10.1089/bfm.2017.0017

Huston RK, et al. 
"Improving Growth for Infants ≤1250 Grams Receiving an Exclusive Human Milk Diet." Nutrients. February 2018.   doi : 10.1002/ncp.10054.

Hair A, et al. "
Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74.  doi :10.1089/bfm.2015.0134.

 
Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459


Reduction of TPN Use (Total Parental Nutrition)

Hair AB, et al."Beyond Necrotizing Enterocolitis: Other Clinical Advantages of an Exclusive Human Milk Diet." Breastfeeding Medicine.http://doi.org/10.1089/bfm.2017.0192
 

Cristofalo EA, et al. “Randomized Trial of Exclusive Human Milk versus Preterm Formula Diets in Extremely Premature Infants.” The Journal of Pediatrics. December 2013. 163(6):1592-1595. doi: 10.1016/j.jpeds.2013.07.011

 

Ghandehari H, et al.“An Exclusive Human Milk-Based Diet in Extremely Premature Infants Reduces the Probability of Remaining on Total Parenteral Nutrition: A reanalysis of the data.”  BMC Pediatrics. 2012. 5: 188. doi:10.1186/1756-0500-5-188.

 


Flexibility of Feeding

Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk FortifierBreastfeed Med. 2017;12(9):570–573. doi:10.1089/bfm.2017.0017

Guidelines for Acute Care of the Neonate (24th Edition). Texas Children/Baylor College. 2016.

 

Abrams SA, et al. “Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products.”  Breastfeeding Medicine. June 2014. 9(6): 281-0285. doi:10.1089/bfm.2014.0024.

 

Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459

 

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

Tabata M, et al. "Fortifier and Cream Improve Fat Delivery in Continuous Enteral Infant Feeding of Breast Milk. Nutrients. 11 February 2015. 7(2): 1174-1183. doi:10.3390/nu7021174.

 


Late Onset of Sepsis

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 


Retinopathy of Prematurity (ROP)

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 


Feeding Intolerance

Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk FortifierBreastfeed Med. 2017;12(9):570–573. doi:10.1089/bfm.2017.0017

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

 


Mortality

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

 

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 
Abrams SA, et al. “Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products.”  Breastfeeding Medicine. June 2014. 9(6): 281-0285. doi:10.1089/bfm.2014.0024.


Ventilation Days

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 


Decreased Length of Stay in the NICU

Hair A, et al. "Premature Infants 750–1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner  Breastfeeding Medicine. April 2016. doi:10.1089/bfm.2015.0166.


Clinical Studies on Humavant CR

Hair A, et al. "Premature Infants 750–1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner  Breastfeeding Medicine. April 2016. doi:10.1089/bfm.2015.0166.
 

Tabata M, et al. "Fortifier and Cream Improve Fat Delivery in Continuous Enteral Infant Feeding of Breast Milk  Nutrients February 2015. doi:10.3390/nu7021174.


Hair A, et al. "Randomized Trial of Human Milk Cream as a Supplement to Standard Fortification of an Exclusive Human Milk-Based Diet in Infants 750-1250 g Birth Weight  J. Peds November 2014.